PUBLICATIONS
SELECTED PUBLICATIONS
Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy.
Nat Commun. 2023 Mar 21;14(1):1549. PMID: 36941274
ABSTRACT
Kidney transplant recipients are at particular risk for developing tumors, many of which are now routinely treated with immune checkpoint inhibitors (ICIs); however, ICI therapy can precipitate transplant rejection. Here, we use TCR sequencing to identify and track alloreactive T cells in a patient with melanoma who experienced kidney transplant rejection following PD-1 inhibition. The treatment was associated with a sharp increase in circulating alloreactive CD8+ T cell clones, which display a unique transcriptomic signature and were also detected in the rejected kidney but not at tumor sites. Longitudinal and cross-tissue TCR analyses indicate unintended expansion of alloreactive CD8+ T cells induced by ICI therapy for cancer, coinciding with ICI-associated organ rejection.
RECENT PUBLICATIONS (selected)
2025
Selamet U, Joachim K, Lin H, Rondon G, Martinez CS, Delgado R, Page V, Motwani SS, Dincer B, Bianchi G, Qazilbash M, Murakami N*, Abudayyeh A*. The Association of Kidney Function on Survival in Patients with AL Amyloidosis after Autologous Stem Cell Transplantation: A Multicenter Study. Kidney360. 2025 Nov doi: 10.34067/KID.0000001036. Epub ahead of print. PMID: 41212634 (* co-senior authors)
Murakami N, Blosser CD, Webber AB, Gupta G, Singh N, Boppana S, Master S, Parasuraman R, Campagnaro EL, Java A, Sprangers B, Bhasin-Chhabra B, Lum E, Khirfan D, Alexander MP, Molnar MZ, Benes B, Thakur AK, Bumma N, Karam S, Hultcrantz M, Bridoux F, Sanchorawala V, Leung N, Landau H. Management recommendations for kidney transplantation in patients with plasma cell dyscrasia. Kidney Int. 2025; 108:780. PMID: 40738478.
Hannouneh Z, Merzkerni M, Hsieh CS, Murakami N. Cellular therapies in transplantation – regulatory T cell therapies and virus-specific therapies. Curr. Transpl. Reports. 2025; 12:33. PMID: 41058937
Saleem N, Wang J, Rejuso A, Teixeira-Pinto A, Stephens JH, Wilson A, Kieu A, Gately RP, Boroumand F, Chung E, Bonevski B, Carlino MS, Carroll R, Lim WH, Craig JC, Murakami N*, Wong G*. Outcomes of Solid Organ Transplant Recipients With Advanced Cancers Receiving Immune Checkpoint Inhibitors: A Systematic Review and Individual Participant Data Meta-Analysis. JAMA Oncol. 2025 Jun 22:e252374. PMID: 40545616. (* co-senior authors)
Herrmann SM, Abudayyeh A, Gupta S, Gudsoorkar P, Klomjit N, Motwani SS, Karam
S, Costa E Silva VT, Khalid SB, Anand S, Kala J, Leaf DE, Murakami N, Rashidi A,
Wanchoo R, Kitchlu A. Diagnosis and management of immune checkpoint inhibitor-
associated nephrotoxicity: a position statement from the American Society of
Onco-nephrology. Kidney Int. 2025 Jan;107(1):21-32. PMID: 39455026.
2024
Kuwabara T, Miyasato Y, Kanki T, Mizumoto T, Matsubara T, Sawa N, Sugiyama H, Maruyama S, Sato H, Tsukamoto T, Murata T, Miyazaki M, Imasawa T, Mukoyama M, Murakami N, Jhaveri KD, Yanagita M; JSN Onconephrology working group. SUrvey of renal Biopsy registry database and Anticancer dRUg therapy in Japan (SUBARU-J study). Clin Kidney J. 2024 Nov 28;17(12):sfae327. PMID: 39664993.
Bigotte Vieira M, Arai H, Nicolau C, Murakami N. Cancer Screening and Cancer Treatment in Kidney Transplant Recipients. Kidney360. 2024 Oct 1;5(10):1569-1583. PMID: 39480669
Hanna GJ, Dharanesswaran H, Giobbie-Hurder A, Harran JJ, Liao Z, Pai L, Tchekmedyian V, Ruiz ES, Waldman AH, Schmults CD, Riella LV, Lizotte P, Paweletz CP, Chandraker AK, Murakami N*, Silk AW*. Cemiplimab for Kidney Transplant Recipients With Advanced Cutaneous Squamous Cell Carcinoma. J Clin Oncol. 2024 Mar 20;42(9):1021-1030. PMID: 38252908. (co-senior authors)
Van Meerhaeghe T, Murakami N, Le Moine A, Brouard S, Sprangers B, Degauque N. Fine-tuning tumor- and allo-immunity: advances in the use of immune checkpoint inhibitors in kidney transplant recipients. Clin Kidney J. 2024 Mar 9;17(4):sfae061. PMID: 38606169.
Murakami N, Wong G. Introduction: Clinical Innovations in Transplant Onconephrology. Semin Nephrol. 2024 Jan;44(1):151493. PMID: 38472079.
Murakami N, Reich AJ, He K, Gelfand SL, Leiter RE, Sciacca K, Adler JT, Lu E, Ong SC, Concepcion BP, Singh N, Murad H, Anand P, Ramer SJ, Dadhania DM, Lentine KL, Lakin JR, Alhamad T. Kidney Transplant Clinicians’ Perceptions of Palliative Care for Patients With Failing Allografts in the US: A Mixed Methods Study. Am J Kidney Dis. 2024 Feb;83(2):173-182.e1. PMID: 37726050.
DiToro D, Murakami N, Pillai S. T-B Collaboration in Autoimmunity, Infection, and Transplantation. Transplantation. 2024 Feb 1;108(2):386-398. PMID: 37314442.
2023
Mizuno H, Murakami N. Multi-omics Approach in Kidney Transplant: Lessons Learned from COVID-19 Pandemic. Curr Transplant Rep. 2023 Dec;10(4):173-187. PMID: 38152593.
Terashita M, Selamet U, Midha S, Nadeem O, Laubach J, Rennke HG, Murakami N. Clinical Outcomes of Monoclonal Gammopathy of Renal Significance Without Detectable Clones. Kidney Int Rep. 2023 Sep 22;8(12):2765-2777. PMID: 38106576.
Abdelrahim M, Esmail A, Abudayyeh A, Murakami N, Victor D, Kodali S, Cheah YL, Simon CJ, Noureddin M, Connor A, Saharia A, Moore LW, Heyne K, Kaseb AO, Gaber AO, Ghobrial RM. Transplant Oncology: An Emerging Discipline of Cancer Treatment. Cancers (Basel). 2023 Nov 9;15(22):5337. PMID: 38001597.
Murakami N, Reich AJ, Pavlakis M, Lakin JR. Conservative Kidney Management in Kidney Transplant Populations. Semin. Nephrol. 43: 15141. PMID: 37499572.
Yeung MY*, Murakami N*, Kafetzi ML*, Simmons DP, Wood I, Macaskill P, Towle M, Della Gatta J, Stevens J, Comeau E, Baronas J, Mohsin N, Chen M, Lee JH, Lane WJ, Milford EL, Guleria I. Impact of allele-specific anti-HLA class I antibodies on organ allocation. Am J Transplant. 2023 May 29:S1600-6135(23)00487-2. PMID: 37257653. (*co-first authors)
Blosser CD, Portuguese AJ, Santana C, Murakami N. Transplant Onconephrology: An Update. Semin Nephrol. 2023 May 18;42(6):151348. PMID: 37209580.
Dunlap GS, DiToro D, Henderson J, Shah SI, Manos M, Severgnini M, Weins A, Guleria I, Ott PA, Murakami N*, Rao DA*. Clonal dynamics of alloreactive T cells in kidney allograft rejection after anti-PD-1 therapy. Nat Commun. 2023 Mar 21;14(1):1549. PMID: 36941274. (*co-senior authors)
Abboud K, Umoru G, Esmail A, Abudayyeh A, Murakami N, Al-Shamsi HO, Javle M, Saharia A, Connor AA, Kodali S, Ghobrial RM, Abdelrahim M. Immune Checkpoint Inhibitors for Solid Tumors in the Adjuvant Setting: Current Progress, Future Directions, and Role in Transplant Oncology. Cancers (Basel). 2023 Feb 23;15(5):1433. PMID: 36900226.
Murakami N, Borges TJ, Win TS, Abarzua P, Tasigiorgos S, Kollar B, Barrera V, Sui SH, Teague JE, Bueno E, Clark RA, Lian CG, Murphy GF, Pomahac B, Riella LV. Low-dose IL-2 promotes immune regulation in face transplantation: A pilot study. Am J Transplant. 2023 Feb 3:S1600-6135(23)00239-3. PMID: 36740193.
Murakami N, Hayden R, Hills T, Al-Samkari H, Casey J, Del Sorbo L, Lawler PR, Sise ME, Leaf DE. Therapeutic advances in COVID-19. Nat Rev Nephrol. 2023 Jan;19(1):38-52. PMID: 36253508.
2022
Bharadwaj P, Shrestha S, Pongracz T, Concetta C, Sharma S, Le Moine A, de Haan N, Murakami N, Riella LV, Holovska V, Wuhrer M, Marchant A, Ackerman ME. Afucosylation of HLA-specific IgG1 as a potential predictor of antibody pathogenicity in kidney transplantation. Cell Rep Med. 2022 Nov 15;3(11):100818. PMID: 36384101.
Ng JH, Izard S, Murakami N, Jhaveri KD, Sharma A, Nair V. Outcomes of kidney transplantation in patients with myeloma and amyloidosis in the US. Nephrol Dial Transplant. 2022 Nov 23;37(12):2569-2580. PMID: 35687020.
Gupta S, Garcia-Carro C, Prosek JM, Glezerman I, Herrmann SM, Garcia P, Abudayyeh A, Lumlertgul N, Malik AB, Loew S, Beckerman P, Renaghan AD, Carlos CA, Rashidi A, Mithani Z, Deshpande P, Rangarajan S, Shah CV, Seigneux S, Campedel L, Kitchlu A, Shin DS, Coppock G, Ortiz-Melo DI, Sprangers B, Aggarwal V, Benesova K, Wanchoo R, Murakami N, Cortazar FB, Reynolds KL, Sise ME, Soler MJ, Leaf DE; ICPi-AKI Consortium Investigators. Shorter versus longer corticosteroid duration and recurrent immune checkpoint inhibitor-associated AKI. J Immunother Cancer. 2022 Sep;10(9):e005646. PMID: 36137651.
Akiyama S, Hamdeh S, Murakami N, Cotter TG, Suzuki H, Tsuchiya K. Pregnancy and neonatal outcomes in women receiving calcineurin inhibitors: A systematic review and meta-analysis. Br J Clin Pharmacol. 2022 Sep;88(9):3950-3961. PMID: 35593302.
Murakami N, Baggett ND, Schwarze ML, Ladin K, Courtwright AM, Goldberg HJ, Nolley EP, Jain N, Landzberg M, Wentlandt K, Lai JC, Shinall MC, Ufere NN, Jones CA, Lakin JR. Top Ten Tips Palliative Care Clinicians Should Know About Solid Organ Transplantation. J Palliat Med. 2022 Jul;25(7):1136-1142. PMID: 35275707.
Gassen RB, Borges TJ, Pérez-Sáez MJ, Zhang H, Al Jurdi A, Llinàs-Mallol L, Aoyama B, Lima M, Pascual J, Sage PT, Murakami N, Riella LV. T cell depletion increases humoral response by favoring T follicular helper cells expansion. Am J Transplant. 2022 Jul;22(7):1766-1778. PMID: 35320600.
Cron DC, Murakami N, Xiang L, Markmann JF, Yeh H, Adler JT. Anastomosis Time and Outcomes after Donation after Circulatory Death Kidney Transplantation. J Am Coll Surg. 2022 Jun 1;234(6):999-1008. PMID: 35703788.
Kawashima S, Joachim K, Abdelrahim M, Abudayyeh A, Jhaveri KD, Murakami N. Immune checkpoint inhibitors for solid organ transplant recipients: clinical updates. Korean Journal of Transplantation. 2022; 36(2): 82-98. PMID: 35919193.
Abdelrahim M, Esmail A, Saharia A, Abudayyeh A, Abdel-Wahab N, Diab A, Murakami N, Kaseb AO, Chang JC, Gaber AO, Ghobrial RM. Utilization of Immunotherapy for the Treatment of Hepatocellular Carcinoma in the Peri-Transplant Setting: Transplant Oncology View. Cancers (Basel). 2022 Mar 30;14(7):1760. PMID: 35406533.
Murakami N, Webber AB, Nair V. Transplant Onconephrology in Patients With Kidney Transplants. Adv Chronic Kidney Dis. 2022 Mar;29(2):188-200.e1. PMID: 35817526.
Murakami N*. Gelfand SL*, Sciacca KR, Kileen K, Leiter RE, Adler JT, Chandraker AK, Lakin JR. Inpatient Kidney Palliative Care for Kidney Transplant Recipients with Failing Allografts. Kidney Med. 2022; 4:100398. PMID: 35243310.
Schreiber B, Abdelrahim M, Abudayyeh A, Murakami N. Emerging Concepts in Managing Malignancy in Kidney Transplant Patients. Semin Nephrol. 2022 Jan;42(1):63-75. PMID: 35618396.
2021
Borges TJ, Murakami N, Lape IT, Gassen RB, Liu K, Cai S, Daccache J, Safa K, Shimizu T, Ohori S, Paterson AM, Cravedi P, Azzi J, Sage PT, Sharpe AH, Li XC, Riella LV. Overexpression of PD-1 on T cells Promotes Tolerance in Cardiac Transplantation via ICOS-Dependent Mechanism. JCI Insight. 2021 Dec 22;6(24):e142909. PMID: 34752418.
Gupta S, Short S.A.P, Sise ME, Prosek JM, Madhavan SM, Soler MJ, Ostermann M, Herrmann SM, Abudayyeh A, Anand S, Glezerman I, Motwani SS, Murakami N, Wanchoo R, Ortiz-Melo DI, Rashidi A, Sprangers B, Aggarwal V, Malik AB, Loew S, Carlos CA, Chang W, Beckerman P, Mithani Z, Shah CV, Renaghan AD, De Seigneux S, Campedel L, Kitchlu A, Shin DS, Rangarajan S, Deshpande P, Coppock G, Eijgelsheim M, Seethapathy HS, Lee M, Strohbehn IA, Owen DH, Husain M, García-Carro C, Bermejo S, Lumlertgul N, Seylanova N, Flanders L, Isik B, Mamlouk O, Lin JS, Garcia P, Kaghazchi A, Khanin Y, Kansal SK, Wauters E, Chandra S, Schmidt-Ott KM, Hsu RK, Tio MC, Mothi SS, Singh H, Schrag D, Jhaveri KD, Reynolds KL, Cortazar FB, Leaf DE. Acute Kidney Injury in Patients Treated with Immune Checkpoint Inhibitors. J Immunother Cancer. 2021 Oct;9(10):e003467. PMID: 34625513. PMC8496384.
Adam BA, Murakami N, Reid G, Du K, Jasim R, Boils CL, Bu L, Hill PD, Murray AG, Renaudin K, Roufosse C, Weins A, Wen K, Riella LV, Mengel M. Gene Expression Profiling in Kidney Transplants With Immune Checkpoint Inhibitor-Associated Adverse Events. Clin J Am Soc Nephrol. 2021; 16:1376. PMID: 34244334. PMC8729568.
Pérez-Sáez MJ, Uffing A, Leon J, Murakami N, Watanabe A, Borges TJ, Sabbisetti V, Cureton P, Kenyon V, Keating L, Yee K, Fernandes Satiro CA, Serena G, Hildebrandt F, Riella CV, Libermann TA, Wallace Wang M, Pascual J, Bonventre JV, Cravedi P, Fasano A, Riella LV. Immunological Impact of a Gluten-Free Dairy-Free Diet in Children with Kidney Disease. Frontiers Immunol. 2021; 12:624821. PMID: 34149688. PMC8208082.
Win TS, Crisler WJ, Dyring-Andersen B, Lopdrup R, Teague JE, Zhan Q, Barrera V, Ho Sui S, Tasigiorgos S, Murakami N, Chandraker A, Tullius SG, Pomahac B, Riella LV, Clark RA. Immunoregulatory and Lipid Presentation Pathways Are Upregulated in Human Face Transplant Rejection. Journal of Clinical Investigation. 2021; 131(8):e135166. PMID: 33667197. PMC8262560.
Murakami N, Mulvaney P, Danesh M, Abudayyeh A, Diab A, Abdel-Wahab N, Abdelrahim M, Khairallah P, Shirazian S, Kukla A, Owoyemi IO, Alhamad T, Husami S, Menon M, Santeusanio A, Blosser C, Zuniga SC, Soler MJ, Moreso F, Mithani Z, Ortiz-Melo D, Jaimes EA, Gutgarts V, Lum E, Danovitch GM, Cardarelli F, Drews RE, Bassil C, Swank JL, Westphal S, Mannon RB, Shirai K, Kitchlu A, Ong S, Machado SM, Mothi SS, Ott PA, Rahma O, Hodi FS, Sise ME, Gupta S, Leaf DE, Devoe CE, Wanchoo R, Nair VV, Schmults CD, Hanna GJ, Sprangers B, Riella LV, Jhaveri KD. A Multi-Center Study on Safety and Efficacy of Immune Checkpoint Inhibitors in Cancer Patients With Kidney Transplant. Kidney Int. 2021; 100(1): 196. PMID: 33359528. PMC8222056.
2020
Danesh MJ, Mulvaney PM, Murakami N, Riella LV, Silk AW, Hanna GJ, Schmults CD. Impact of Corticosteroids on Allograft Protection in Renal Transplant Patients Receiving anti-PD-1 Immunotherapy. Cancer Immunol Immunother. 2020;69 (9):1937-1941. PMID: 32588077. PMC7479641.
Cortazar FB, Kibbelelaar ZA, Glezerman IG, Abudayyeh A, Mamlouk O, Motwani SS, Murakami N, Herrmann SM, Manohar S, Shirali AC, Kitchlu A, Shirazian S, Assal A, Vijayan A, Renaghan AD, Ortiz-Melo DI, Rangarajan S, Malik BA, Hogan JJ, Dinh AR, Shin DS, Marrone KA, Mithani Z, Johnson DB, Hosseini A, Uprety D, Sharma S, Gupta S, Reynolds KL, Sise ME, Leaf DE. Clinical Features and Outcomes of Immune Checkpoint Inhibitor-Associated AKI: A Multicenter Study. J Am Soc Nephrol. 2020;31(2):435-446. PMID: 31896554. PMC7003302.
2019
Magee CN*, Murakami N*, Borges TJ, Shimizu T, Safa K, Ohori S, Cai S, Uffing A, Azzi J, Elyaman W, Charbonnier LM, Liu K, Toprak D, Visner G, Chatila TA, Siebel CW, Najafian N, Riella LV. Notch-1 Inhibition Promotes Immune Regulation in Transplantation Via Regularory T Cell-Dependent Mechanisms. 2019; 140:846-63. PMID: 31266349. PMC6722011.
MURAKAMI LAB 